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Open Journal Systems (OJS) is a FOSS tool that allows you to publish and manage peer-reviewed open access journals. It provides the technical infrastructure for the online presentation of the journal articles, as well as a framework for editorial management, including article submission, multiple rounds of peer-review, and indexing. There are over 10,000 OJS installations around the world, with OJS being used for traditional journals as well as for reports, learning management systems, courses, monographs, and more. OJS was created by the Public Knowledge Project, a partnership between four North American universities. 
The software itself is designed so that you can build up your installation from a core via 'plug-ins', so that installing new developments does not require a complete change of the entire code base. Some of the tools that have already been developed include facilitating indexing in Google Scholar, providing RS/Atom syndication feeds, and facilitating COUNTER statistics generation and reporting.
OJS is written in PHP, and uses either a MySQL or a PostgreSQL database. It can be hosted on Windows or Unix servers.
OJS has already been translated into: English, French, Russian, Portuguese, Spanish, German, Italian and Turkish. Ten more languages are in development, including Arabic, Chinese, Thai and Hindi.
Read the news article about the online Themed Week session on OJS, including details of the session recording and presentations.
Read a case study describing work with OJS in Lithuania.
Find out more about PKP School: OJS for Journal Managers (this course is designed to help journal managers learn to make the most of OJS).
Find out more about SUNJournals: the implementation of a platform to host open access online journals, a collaborative effort between the Library and Information Service and departments and units affiliated with the University of Stellenbosch, OJS open source software is used as a hosting platform, includes help pages, e.g installation notes.